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Dimesna

Product #: TS0529
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Details

l  General Information

Product Name

Dimesna

General description

Dimesna is an uroprotective agent used to decrease urotoxicity.

Synonym

BNP-7787; disodium; 2-(2-sulfonatoethyldisulfanyl)ethanesulfonate

Purity

≥98.0%(HPLC)

CAS Number

16208-51-8

Formula

C4H8Na2O6S4

Molecular Weight

326.322

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥50mg/ml

Ethanol

Insoluble

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Dimesna is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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