Product Name

Desmopressin Acetate

General description

Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).

Purity

≥98.0%(HPLC)

Peptide content

≥70.0%

Formula

C⁴⁶H⁶⁴N¹⁴O¹²S  · xC²H⁴O² · yH²O

Molecular Weight

1069.224(anhydrous free base basis)

CAS Number

16679-58-6

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White Powder

Solubility(25°C)

DMSO

≥45mg/ml

Water

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin  stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov