l General Information |
Product Name | Ataluren |
General description | Ataluren selectively induces ribosomal read-through of premature but not normal termination codons. |
Synonym | 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid; PTC124 |
Purity | ≥98.0%(HPLC) | CAS Number | 775304-57-9 |
Formula | C15H9FN2O3 | Molecular Weight | 284.24 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Ataluren selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
