Product Name

Fluoxetine HCl

General description

Fluoxetine HCl is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane.

Synonym

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

56296-78-7

Formula

C¹⁷H¹⁸F³NO·HCl

Molecular Weight

345.79

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

~4mg/mL

l  Biological Information

Biochem/Physiol  Actions

Fluoxetine Hydrochloride is the hydrochloride salt form of fluoxetine, a diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, antiobsessional and antibulimic effects. Fluoxetine binds to the presynaptic serotonin receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5HT1(serotonin) receptors leading to antidepressant, antiobsessional and antibulimic effects via various nerve pathways in the brain.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov