l General Information |
Product Name | TH588 |
General description | TH588 is a potent and selective MTH1 (NUDT1) inhibitor. |
Synonym | 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine |
Purity | ≥98.0%(HPLC) | CAS Number | 1609960-31-7 |
Formula | C13H12Cl2N4 | Molecular Weight | 295.17 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | ≥15mg/mL(warmed) |
Ethanol | ~1mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
