l General Information |
Product Name | Daptomycin |
General description | Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
Synonym | LY146032 |
Purity | ≥99.0%(HPLC) | CAS Number | 103060-53-3 |
Formula | C72H101N17O26 | Molecular Weight | 1620.67 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | ≥50mg/mL(warmed) |
Ethanol | Insoluble |
Water | ≥50mg/mL(warmed) |
l Biological Information |
Biochem/Physiol
Actions | Daptomycin is a semi-synthetic cyclic lipopeptide antibiotic isolated from the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
