l General Information |
Product Name | LY364947 |
General description | LY364947 is a potent ATP-competitive inhibitor of TGFβR-I. |
Synonym | 4-(5-pyridin-2-yl-1H-pyrazol-4-yl)quinoline; HTS 466284 |
Purity | ≥98.0%(HPLC) | CAS Number | 396129-53-6 |
Formula | C17H12N4 | Molecular Weight | 272.3 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | ~1mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
