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LDN-193189

Product #: TS0341
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Details

l  General Information

Product Name

LDN-193189

General description

LDN-193189 is a selective BMP signaling inhibitor.

Synonym

4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; DM3189

Purity

≥98.0%(HPLC)

CAS Number

1062368-24-4

Formula

C25H22N6

Molecular Weight

406.48

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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