Product Name

NSC 23766 trihydrochloride

General description

NSC 23766 trihydrochloride is an inhibitor of Rac GTPase.

Synonym

6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine; trihydrochloride

Purity

≥98.0%(HPLC)

CAS Number

1177865-17-6

Formula

C²⁴H³⁵N⁷·3HCl

Molecular Weight

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

≥50mg/mL(warmed)

Ethanol

Insoluble

Water

≥50mg/mL(warmed)

l  Biological Information

Biochem/Physiol  Actions

NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov