Product Name

FRAX597

General description

FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs.

Synonym

6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one

Purity

≥98.0%(HPLC)

CAS Number

1286739-19-2

Formula

C²⁹H²⁸ClN⁷OS

Molecular Weight

558.10

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥10mg/mL(warmed)

Ethanol

~1mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov