Product Name

Cilengitide trifluoroacetate

General description

Cilengitide trifluoroacetate is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor.

Synonym

2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid; 2,2,2-trifluoroacetic acid; EMD 121974, NSC 707544

Purity

≥98.0%(HPLC)

CAS Number

199807-35-7

Formula

C²⁹H⁴¹F³N⁸O⁹

Molecular Weight

702.68

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥5mg/mL

l  Biological Information

Biochem/Physiol  Actions

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov