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R406

Product #: TS0208
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Details

l  General Information

Product Name

R406

General description

R406 is a potent Syk inhibitor.

Synonym

benzenesulfonic acid; 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

Purity

98.0%(HPLC)

CAS Number

841290-81-1

Formula

C28H29FN6O8S

Molecular Weight

628.63

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25)

DMSO

≥50mg/mL

Ethanol

Very slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

R406 is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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