Product Name

NVP-ADW742

General description

NVP-ADW742 is an IGF-1R inhibitor.

Synonym

5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine; GSK 552602A; ADW742

Purity

≥98.0%(HPLC)

CAS Number

475488-23-4

Formula

C²⁸H³¹N⁵O

Molecular Weight

453.58

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

≥5mg/mL(warmed）

Ethanol

~3mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

l  Packaging & Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov