l General Information |
Product Name | JNJ-38877605 |
General description | JNJ-38877605 is an ATP-competitive inhibitor of c-Met. |
Synonym | 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline |
Purity | ≥98.0%(HPLC) | CAS Number | 943540-75-8 |
Formula | C19H13F2N7 | Molecular Weight | 377.35 |
Suitability | BioReagent,
suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥35mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. |
Application | JNJ-38877605 has been used in trials studying the treatment of Neoplasms. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
