Phone:| Tech Support:| E-mail:

BMS-777607

Product #: TS0196
Image SKU-Pack Size Stock Price($) Quantity

Documents

Details

l  General Information

Product Name

BMS-777607

General description

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.

Synonym

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

Purity

98.0%(HPLC)

CAS Number

1025720-94-8

Formula

C25H19ClF2N4O4

Molecular Weight

512.89

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

≥45mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

Application

BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

天问科技