Product Name

AG-490 (Tyrphostin B42)

General description

AG-490 (Tyrphostin B42) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk  and Src.

Synonym

(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; Zinc02557947

Purity

≥98.0%(HPLC)

CAS Number

133550-30-8

Formula

C¹⁷H¹⁴N²O³

Molecular Weight

294.30

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥5mg/mL

Water

Insoluble

l  Biological Information

Application

1. Enzyme Inhibitors

2. Antineoplastic Agents

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov