Product Name

Oltipraz

General description

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.

Synonym

4-methyl-5-pyrazin-2-yldithiole-3-thione; BRN 0978110, CCRIS 4048, NSC 347901, RP 35972

Purity

≥98.0%(HPLC)

CAS Number

64224-21-1

Formula

C⁸H⁶N²S³

Molecular Weight

226.34

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

≥35mg/mL(warmed)

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).

Application

1. Reverse Transcriptase Inhibitors

2. Antiviral Agents

3. Anticarcinogenic Agents

4. Schistosomicides

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov