l General Information |
Product Name | Piperlongumine |
General description | Piperlongumine, a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. |
Synonym | 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one; Piplartine; Piplartin |
Purity | ≥98.0%(HPLC) | CAS Number | 20069-09-4 |
Formula | C17H19NO5 | Molecular Weight | 317.34 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥15mg/mL(warmed) |
Ethanol | ≥5mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Piperlongumine, a natural alkaloid from Piper longum L, increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
