Angiogenesis
Apoptosis
Autophagy
Cell Cycle
Cytoskeletal Signaling
DNA Damage
Endocrinology&Hormones
Epigenetics
ER stress & UPR
GPCR & G Protein
Immunology&Inflammation
JAK/STAT
MAPK
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Metabolism
Microbiology
Natural products
Neuronal Signaling
NF-κB
PI3K/Akt/mTOR
Proteases
Protein Tyrosine Kinase
Stem Cells & Wnt
TGF-beta/Smad
Transmembrane Transporters
Ubiquitin
Others
Screening library
Peptide
Enzymes and proteins
Sphingolipids
Amino acid
Carbohydrates
Dyeing and dyes
Nucleotides
Vitamins
Analytical Standards
Drug impurity
Derivative analytical reagent
Chromatographic solvent
Analysis materials
Chiral compounds
Amino acid derivatives
Catalysts and Ligands
Benzene ring compounds
Indole compounds
Pyridine compounds
Other heterocyclic compounds
Other synthetic blocks
Inorganic salt
Proteins and Peptides
Analysis and preparation
Chiral analysis and preparation
Customized synthesis
>
JIB-04
TS0144-10MG
In-stock
165.2
- +
TS0144-25MG
350
l General Information
Product Name
General description
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
Synonym
5-chloro-N-[(E)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine; NSC 693627
Purity
≥98.0%(HPLC)
CAS Number
199596-05-9
Formula
C17H13ClN4
Molecular Weight
308.76
Suitability
BioReagent, suitable for cell culture, etc.
l Physical and Chemical Information
Appearance
solid
Solubility(25℃)
DMSO
≥20mg/mL(warmed)
Ethanol
Insoluble
Water
l Biological Information
Biochem/Physiol Actions
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively.
l Storage
Storage temp.
-20℃
l Precautions and Disclaimer
This product is for R&D use only, not for drug, household, or other uses.
l References
1. http://www.drugbank.ca
2. https://ncit.nci.nih.gov
3. https://www.ncbi.nlm.nih.gov
