l General Information |
Product Name | GSK J4 HCl |
General description | GSK J4 HCl is a cell permeable prodrug of GSK J1. |
Purity | ≥98.0%(HPLC) | CAS Number | 1373423-53-0(free base) |
Formula | C24H27N5O2·HCl | Molecular Weight | 453.96 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL(warmed) |
Ethanol | ≥50mg/mL(warmed) |
Water | ≥50mg/mL |
l Biological Information |
Biochem/Physiol
Actions | GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
