l General Information |
Product Name | EPZ015666(GSK3235025) |
General description | EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor. |
Synonym | N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide |
Purity | ≥98.0%(HPLC) | CAS Number | 1616391-65-1 |
Formula | C20H25N5O3 | Molecular Weight | 383.44 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL(warmed) |
Ethanol | ≥45mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |