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EPZ015666(GSK3235025)

Product #: TS0139
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Details

l  General Information

Product Name

EPZ015666(GSK3235025)

General description

EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor.

Synonym

N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

Purity

≥98.0%(HPLC)

CAS Number

1616391-65-1

Formula

C20H25N5O3

Molecular Weight

383.44

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

≥50mg/mL(warmed)

Ethanol

≥45mg/mL(warmed)

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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