l General Information |
Product Name | GSK343 |
General description | GSK343 is a potent and selective EZH2 inhibitor. |
Synonym | N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide |
Purity | ≥98.0%(HPLC) | CAS Number | 1346704-33-3 |
Formula | C31H39N7O2 | Molecular Weight | 541.69 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMF | ≥5mg/mL(warmed) |
Ethanol | ~4mg/mL |
Water | ~1mg/mL(warmed) |
l Biological Information |
Biochem/Physiol
Actions | GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
