l General Information |
Product Name | Pinometostat (EPZ5676) |
General description | Pinometostat is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L. |
Synonym | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol |
Purity | ≥98.0%(HPLC) | CAS Number | 1380288-87-8 |
Formula | C30H42N8O3 | Molecular Weight | 562.71 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL(warmed) |
Ethanol | ≥50mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Pinometostat is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. |
Application | Pinometostat has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
