l General Information |
Product Name | (-)-Parthenolide |
General description | (-)-Parthenolide is a sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). |
Synonym | Parthenolide |
Purity | ≥98.0%(HPLC) | CAS Number | 20554-84-1 |
Formula | C15H20O3 | Molecular Weight | 248.322 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥45mg/mL |
Ethanol | ≥45mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | (-)-Parthenolide is a sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). It has a role as a non steroidal anti-inflammatory drug, a non-narcotic analgesic, a peripheral nervous system drug and an inhibitor. (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions. |
Application | Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
