l General Information |
Product Name | Sodium butyrate |
General description | Sodium butyrate, sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). |
Synonym | sodium; butanoate; Butyric acid sodium salt |
Purity | ≥98.0%(HPLC) | CAS Number | 156-54-7 |
Formula | C4H7NaO2 | Molecular Weight | 110.088 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | Insoluble |
Ethanol | ≥20mg/mL |
Water | ≥20mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the of other genes and proteins involved in cellular differentiation and apoptotic signaling. |
Application | Histamine Antagonists |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
