l General Information |
Product Name | Givinostat (ITF2357) |
General description | Givinostat is a potent HDAC inhibitor. |
Synonym | [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrate; hydrochloride; Givinostat hydrochloride hydrate |
Purity | ≥98.0%(HPLC) | CAS Number | 732302-99-7 |
Formula | C24H30ClN3O5 | Molecular Weight | 475.97 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ~3mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Givinostat is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. |
Application | Histone Deacetylase Inhibitors |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
