Product Name

Dorsomorphin (Compound C) 2HCl

General description

Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor.

Synonym

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; dihydrochloride; BML-275 2HCl,Compound C 2HCl

Purity

≥98.0%(HPLC)

CAS Number

1219168-18-9

Formula

C²⁴H²⁷Cl²N⁵O

Molecular Weight

472.41

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

Insoluble

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Dorsomorphin 2HCl is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits typeⅠBMP receptor activity.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov