l General Information |
Product Name | Tideglusib |
General description | Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor. |
Synonym | 4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione; NP031112, NP-12 |
Purity | ≥98.0%(HPLC) | CAS Number | 865854-05-3 |
Formula | C19H14N2O2S | Molecular Weight | 334.39 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥5mg/mL(warmed) |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Tideglusib is under the investigation for the development of treatments for Alzheimer's disease and for progressive supranuclear palsy. It is reported to be a potent anti-inflammatory and neuroprotective that is a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3). Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
