Temsirolimus (CCI-779, NSC 683864)
Product #：
TS0024
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TS0024-5MG
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96
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TS0024-10MG
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Details
l General Information |
Product Name | Temsirolimus (CCI-779, NSC 683864) |
General description | Temsirolimus is a specific mTOR inhibitor. |
Synonym | 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]-rapamycin |
Purity | ≥98.0%(HPLC) | CAS Number | 162635-04-3 |
Formula | C56H87NO16 | Molecular Weight | 1030.29 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥50mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Temsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. |
Application | Temsirolimus is an inhibitor of cell proliferation and anticancer agent that is used as treatment of advanced renal cell cancer. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
