Product Name

IC-87114

General description

IC-87114 is a selective PI3Kδ inhibitor.

Synonym

2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one

Purity

≥98.0%(HPLC)

CAS Number

371242-69-2

Formula

C²²H¹⁹N⁷O

Molecular Weight

397.43

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

solid

Solubility(25℃)

DMSO

Very slightly soluble

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

IC-87114 is a member of the class of quinazolines that is quinazolin-4(3H)-one carrying (6-amino-9H-purin-9-yl)methyl, 2 methylphenyl and methyl substituents at positions 2, 3 and 5 respectively. It has a role as a PIK3 inhibitor. It is a member of quinazolines, a member of 6-aminopurines and a biaryl.

IC-87114 is a selective PI3Kδ inhibitor with IC50 of 0.5 μM in a cell-free assay, 58-fold more selective for PI3Kδ than PI3Kγ, and over 100-fold more selective than PI3Kα/β.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov