l General Information |
Product Name | NU7441(KU-57788) |
General description | NU7441(KU-57788) is a highly potent and selective DNA-PK inhibitor. |
Synonym | 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one |
Purity | ≥98.0%(HPLC) | CAS Number | 503468-95-9 |
Formula | C25H19NO3S | Molecular Weight | 413.49 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ~4mg/mL(warmed) |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM in cell-free assays. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
