Product Name

Fosinopril Sodium

General description

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Synonym

SQ28555

Purity

≥98.0%(HPLC)

CAS Number

88889-14-9

Formula

C³⁰H⁴⁵NNaO⁷P

Molecular Weight

585.654

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White powder

Solubility(25°C)

DMSO

Insoluble

Ethanol

~5mg/mL

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Fosinopril Sodium is the sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium.

l  Storage

Storage temp.

0-5°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov