l General Information |
Product Name | Carmustine |
General description | Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms. |
Synonym | bis-chloroethylnitrosourea; BCNU; 1,3-bis(2-chloroethyl)-1-nitrosourea |
Purity | ≥98.0%(HPLC) | CAS Number | 154-93-8 |
Formula | C5H9Cl2N3O2 | Molecular Weight | 214.046 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Light yellow to Yellow amorph Solid or oily Liquid |
l Biological Information |
Biochem/Physiol
Actions | Carmustine is an antineoplastic nitrosourea. Carmustine alkylates and cross-s DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
