l General Information |
Product Name | Metyrapone |
General description | Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. |
Synonym | 2-methyl-1,2-dipyridin-3-ylpropan-1-one |
Purity | ≥99.0%(HPLC) | CAS Number | 54-36-4 |
Formula | C14H14N2O | Molecular Weight | 226.27376 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White solid |
Solubility(25°C) | DMSO | ≥35mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Metyrapone is a pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
