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Sumatriptan succinate

Product #: TL1115
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l  General Information

Product Name

Sumatriptan Succinate

General description

Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.

Synonym

GR 43175; butanedioic acid; 1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide

Purity

≥99.0%(HPLC)

CAS Number

103628-48-4

Formula

C18H27N3O6S

Molecular Weight

413.489

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Beige solid

Solubility(25°C)

DMSO

≥45mg/ml

Ethanol

Insoluble

Water

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Sumatriptan Succinate is the succinate salt form of sumatriptan, a member of the triptan class of compounds with anti migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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