Product Name

Tolterodine tartrate

General description

Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.

Synonym

PNU-200583E; (2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol

Purity

≥97.0%(HPLC)

CAS Number

124937-52-6

Formula

C²⁶H³⁷NO⁷

Molecular Weight

475.582

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

~5mg/mL

Water

≥5mg/mL

l  Biological Information

Biochem/Physiol  Actions

Tolterodine Tartrate is the tartrate salt form of tolterodine, a benzhydryl compound and a muscarinic receptor antagonist possessing both antimuscarinic and antispasmodic properties. Both tolterodine and its active metabolite, 5 hydroxymethyltolterodine, competitively blocks muscarinic receptors, thereby inhibiting acetylcholine receptor binding. This antagonistic action results in an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, indicating an antimuscarinic action on the lower urinary tract. The 5-hydroxymethyl metabolite appears to contribute significantly to the therapeutic effects.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov