Product Name

Mizolastine

General description

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Purity

≥98.0% (HPLC)

CAS Number

108612-45-9

Formula

C²⁴H²⁵FN⁶O

Molecular Weight

432.49

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25°C)

DMSO

Insoluble

0.5M NaOH

~5mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov