l General Information |
Product Name | Valdecoxib |
General description | Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM. |
Synonym | 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide |
Purity | ≥99.0%(HPLC) | CAS Number | 181695-72-7 |
Formula | C16H14N2O3S | Molecular Weight | 314.359 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | white to off-white solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Ethanol | ≥5mg/ml |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
