Product Name

Clemastine Fumarate

General description

Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.

Synonym

(E)-but-2-enedioic  acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

Purity

≥98.0%(HPLC)

CAS Number

14976-57-9

Formula

C²⁵H³⁰ClNO⁵

Molecular Weight

459.96

Suitability

BioReagent,  suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25℃)

DMSO

≥30mg/mL(warmed)

Ethanol

Slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. Clemastine fumarate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. This drug also prevents histamine induced pain and itching of mucous membranes.

Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov