l General Information |
Product Name | Sasapyrine |
General description | Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent. |
Synonym | NSC-49171; 2-(2-hydroxybenzoyl)oxybenzoic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 552-94-3 |
Formula | C14H10O5 | Molecular Weight | 258.229 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Ethanol | ≥45mg/ml |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities. As a prodrug, salsalate is hydrolyzed to salicylic acid which inhibits the of cyclooxygenase (COX) enzymes. This prevents the conversion of arachidonic acid into prostaglandin precursors and leads to decreased formation of prostaglandins that are involved in pain, fever and inflammation. In addition, salsalate appears to inhibit nuclear factor-kappa B (NF-kB), thereby preventing activation of the NF-kB-mediated pathway and the of genes involved in inflammation. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
