l General Information |
Product Name | Aprepitant |
General description | Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. |
Synonym | MK-0869; L-754030 |
Purity | ≥98.0%(HPLC) | CAS Number | 170729-80-3 |
Formula | C23H21F7N4O3 | Molecular Weight | 534.43 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | solid |
Solubility(25℃) | DMSO | ≥50mg/mL |
Ethanol | ≥10mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. Aprepitant is a potent and selective neurokinin 1 receptor antagonist with IC50 of
0.1 nM. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
