l General Information |
Product Name | Sulindac sulfone |
General description | Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. |
Synonym | Sulindac EP Impurity B |
Purity | ≥97.0%(HPLC); ≥98.0%(TLC) | CAS Number | 59864-04-9 |
Formula | C20H17FO4S | Molecular Weight | 372.41 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Light Yellow to Dark Yellow |
Solubility(25°C) | DMSO | >25mg/mL |
Ethanol | >10mg/mL(warmed) |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Sulindac sulfone is a sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor. It has a role as a cyclooxygenase 2 inhibitor, an EC 1.13.11.34 (arachidonate 5 lipoxygenase) inhibitor and an apoptosis inducer. It is a sulfone, a monocarboxylic acid and an organofluorine compound. It derives from a sulindac. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
