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Fluvastatin

Product #: TL0948
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Details

l  General Information

Product Name

Fluvastatin

General description

Fluvastatin is the first synthetically-derived HMG-CoA reductase inhibitor.

Synonym

Lescol

Purity

≥98.0%(HPLC)

CAS Number

93957-54-1

Formula

C24H26FNO4

Molecular Weight

411.473

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

≥25mg/mL

l  Biological Information

Biochem/Physiol  Actions

Fluvastatin, the first synthetically-derived HMG-CoA reductase inhibitor, is a hydrophilic, acidic, antilipemic agent used to lower cholesterol and triglyceride levels associated with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb), to slow the progression of coronary atherosclerosis in patients with CHD and as secondary prevention therapy in patients with CHD to reduce the risk of requiring coronary revascularization procedures. Although similar to lovastatin, simvastatin, and pravastatin, fluvastatin has a shorter half-life, no active metabolites, extensive protein binding, and minimal CSF penetration. Fluvastatin acts primarily in the liver. It is prepared as a racemate of two erythro enantiomers of which the 3R,5S enantiomer exerts the pharmacologic effect.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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