l General Information |
Product Name | MK-2206 2HCl |
General description | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3. |
Synonym | 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2~{H}-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one; dihydrochloride |
Purity | ≥98%(HPLC) | CAS Number | 1032350-13-2 |
Formula | C25H23Cl2N5O | Molecular Weight | 480.393 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Pale yellow or yellow solid |
Solubility(25°C) | DMSO | ≥50mg/mL |
Ethanol | Insoluble |
Water | ≥25mg/mL |
l Biological Information |
Biochem/Physiol
Actions | MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
