Product Name

Neomycin sulfate

General description

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity.

Synonym

Framycetin sulfate; Neomycin B sulphate; Framycin sulfate

Purity

≥97%(HPLC)

CAS  Number

1405-10-3

Formula

C²³H⁴⁶N⁶O¹³ • H²SO⁴

Molecular  Weight

712.72

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Beige solid

Solubility(25°C)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational shift, thereby results in premature termination. This eventually leads to bacterial cell death.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov