l General Information |
Product Name | Donepezil Hydrochloride |
General description | Donepezil hydrochloride is an indan and piperidine derivative that acts as a selective and reversible inhibitor of Acetylcholinesterase. |
Synonym | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; hydrochloride |
Purity | ≥99.0%(HPLC) | CAS Number | 120011-70-3 |
Formula | C24H30ClNO3 | Molecular Weight | 415.958 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White solid |
Solubility(25℃) | DMSO | Slightly soluble |
Ethanol | Slightly soluble |
Water | ≥10mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Donepezil Hydrochloride is the hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. |
Application | 1.Nootropic Agents 2.Cholinesterase Inhibitors |
l Storage |
Storage temp. | 0-5℃ |
l Precautions and Disclaimer |
This
product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
