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Moxonidine hydrochloride

Product #: TL0884
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l  General Information

Product Name

Moxonidine hydrochloride

General description

Moxonidine hydrochloride is a new generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension.

Synonym

6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine; hydrochloride; Normoxocin hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

75438-58-3

Formula

C9H15Cl2N5O

Molecular Weight

280.153

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

l  Biological Information

Biochem/Physiol  Actions

Moxonidine (INN) is a new generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction. Moxonidine is a selective agonist at the imidazoline receptor subtype 1 (I1). This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata. Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.

Application

Antihypertensive Agents

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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