Product Name

Pamidronate disodium pentahydrate

General description

Pamidronate disodium pentahydrate is an aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions.

Synonym

disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate; pentahydrate

Purity

≥98.0%(HPLC)

CAS Number

109552-15-0

Formula

C³H⁹NNa²O⁷P² · 5H²O

Molecular Weight

369.11

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or Off-white solid

Solubility(25℃)

DMSO

Very slightly soluble

Ethanol

Insolube

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Pamidronate Disodium is the disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.

Application

Pamidronate disodium is an aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov