Product Name

Quinine hydrochloride dihydrate

General description

Quinine hydrochloride dihydrate is an alkaloid derived from the bark of the cinchona tree.

Synonym

(8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate

Purity

≥98.0%(HPLC)

CAS Number

6119-47-7

Formula

C²⁰H²⁹ClN²O⁴

Molecular Weight

396.91

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

≥40mg/mL

l  Biological Information

Biochem/Physiol  Actions

Quinine hydrochloride dihydrate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

Application

1. Analgesics, Non-Narcotic

2. Antimalarials

3. Muscle Relaxants, Central

l  Storage

Storage  temp.

2-8℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov