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Quinine hemisulfate salt monohydrate

Product #: TL0874
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l  General Information

Product Name

Quinine hemisulfate salt monohydrate

General description

Quinine hemisulfate salt monohydrate is an alkaloid derived from the bark of the cinchona tree.

Synonym

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dehydrate; Quinine sulfate; Quinine sulfate (2:1) (salt) dihydrate

Purity

≥99.0%(HPLC)

CAS Number

207671-44-1

Formula

C40H54N4O10S

Molecular Weight

782.95

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White solid

Solubility(25℃)

DMSO

≥25mg/mL

Water

≥25mg/mL

l  Biological Information

Biochem/Physiol  Actions

Quinine bisulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

Application

1. Analgesics, Non-Narcotic

2. Antimalarials

3. Muscle Relaxants, Central

l  Storage

Storage temp.

2-8℃

l  Precautions and Disclaimer

This  product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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